Biotech Scientist II (Drug Discovery)
LMI is seeking a Scientist to support Walter Reed Army Institute of Research, Experimental Therapeutics Branch (WRAIR ET) and its collaborating institutions in the conduct of biomedical research that is responsive to Department of Defense (DoD) and U.S. Army requirements. WRAIR ET’s mission is to is to discover and develop new therapeutic agents to protect military members from death, disease, and injury. Collectively, ET engages in drug discovery, drug efficacy and mechanism evaluation, formal preclinical and clinical development. The Branch also contributes to Graduate Medical Education via the Clinical Pharmacology Fellowship – the only fellowship of its kind within the DoD.
LMI is a consultancy dedicated to powering a future-ready, high-performing government, drawing from expertise in digital and analytic solutions, logistics, and management advisory services. We deliver integrated capabilities that incorporate emerging technologies and are tailored to customers’ unique mission needs, backed by objective research and data analysis. Founded in 1961 to help the Department of Defense resolve complex logistics management challenges, LMI continues to enable growth and transformation, enhance operational readiness and resiliency, and ensure mission success for federal civilian and defense agencies.
LMI offers a generous compensation package with excellent benefits that start the first day of employment. Business casual dress, flex time, and tuition reimbursement are a few of our many work-life benefits available to our employees.
- Provide in vitro metabolism and disposition experimental support to include the design and execution of high-throughput cell-based assays in efforts related to discovery and development of new therapeutic drugs.
- Design, implement, and perform in vitro permeability studies utilizing high throughput robotic systems and appropriate cell lines to assess permeability and potential for drug metabolism.
- Design, implement, and perform standard or novel procedures for assessing in vitro drug metabolism using recombinant enzymes and tissue fractions that include recombinant Cytochrome P450s, liver microsomes, primary hepatocytes, and additional enzyme-based assays to assess drug metabolism.
- Implement analytical methods for candidate drugs and metabolites using liquid chromatography coupled with mass spectrometry, in support of metabolic profiling and preclinical drug pharmacokinetic studies.
- Train junior lab members in the procedures required for cell culture and assay performance as required.
- Collaborate in the development and validation of analytical methods for the identification of candidate new drugs and putative metabolites using high performance liquid chromatography (HPLC) with ultraviolet-visible spectroscopy (UV/Vis), fluorescence, electrochemical detection, radioactive monitor analyses, and/or mass spectrometry as needed.
- Analyze data and prepare reports in support of Investigational New Drugs and New Drug Applications through the US Food and Drug Administration (FDA) using standardized computer applications and relevant software.
- Generate and maintain detailed laboratory records and related summaries and reports, all of which remain property of the WRAIR.
- Prepare and present novel research projects as abstracts and/or for submission for the peer review publication process.
- Comply with all specified guidelines regarding safety, security, standard operating procedures, written protocols, technical manuals, and procurement of supplies/equipment as per WRAIR regulations.
- PhD in Chemistry, Analytic Chemistry, Biochemistry, Molecular Biology, Bio-physics, Chemical Biology, Biology or related field
- Min 5 years experience
- Must be able to obtain and maintain a Secret US government clearance; US citizenship required